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An In Vitro Physiological Study of Normal and Unstable Human Detrusor Muscle
Author(s) -
EATON A. C.,
BATES C. P.
Publication year - 1982
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1982.tb13618.x
Subject(s) - detrusor muscle , detrusor instability , contractility , in vitro , muscle contraction , urinary bladder , medicine , urology , chemistry , anatomy , urinary system , biochemistry
Summary— A systemati in vitro physiological study of isolated human detrusor muscle strips is reported. Detrusor strips were obtained at operation. Pre‐operativeurodynamic studies enabled specimens to be classified as normal or unstable. Comparisons were made between responses of normal and unstable detrusor strips. The results provide evidence of a previously undescribed feedback‐loop operating via pre‐synaptic alpha‐adrenoceptors which controls detrusor contractility. Further evidence is provided suggesting that an imbalance in this system is present in unstable detrusor muscle.