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An Experimental Study of the Anatomy of the Tubules of the Human Kidney and its Relation to Calculus Formation
Author(s) -
GRAVES F. T.
Publication year - 1982
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1982.tb13598.x
Subject(s) - lumen (anatomy) , anatomy , human kidney , medulla , kidney , renal medulla , tubule , biology , medicine , medullary cavity , microbiology and biotechnology
Summary— During a period of 28 years 6 clinical observations concerning humans and a dog indicated that micro‐calculi can form and acquire laminated growth at the base of the papillae in the renal medulla. In the subsequent research, plastic casts were made of the distal tubules of human post mortem kidneys. Study of these showed that acute angle and Z‐bends were more prevalent at the basesofthe papillae in the lower calices. Macro‐photographs revealed that kinks in the wall of the tubule can reduce the lumen at these points. The combined evidence suggests that crystals and cellular debris may become impacted at these sites and form the nucleus of a stone.