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Natural Killer Cell Activity and Response to Phytohaemagglutinin Compared with the Histological Diagnosis of Patients with Transitional Cell Carcinoma of the Bladder
Author(s) -
BRITTEN VERONICA,
REES R. C.,
CLEGG A.,
SMITH G. T.,
POTTER C. W.,
FOX M.,
WILLIAMS J. L.
Publication year - 1982
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1982.tb06972.x
Subject(s) - phytohaemagglutinin , transitional cell carcinoma , cell , medicine , carcinoma , immune system , disease , natural killer cell , urinary bladder , immunology , stage (stratigraphy) , pathology , bladder cancer , oncology , cytotoxicity , in vitro , biology , cancer , paleontology , biochemistry , genetics
Summary— In vitro tests of immune reactivity in patients with transitional cell carcinoma (TCC) of the urinary bladder were compared with the clinical and histological diagnosis. Response of peripheral blood lymphocytes to the mitogen phytohaemagglutinin (PHA) tended to be reduced in patients with more advanced disease, although the difference between patients with advanced disease and those with early disease or controls was not statistically significant (P>0.05). Assessment of natural killer (NK) cell activity in the same patients showed no change in levels of reactivity at any stage of the disease. There was no difference between the NK cell activity of patients with TCC of the bladder and normal controls.