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The Clinical Significance of Tissue Polypeptide Antigen (TPA) in the Urine of Bladder Cancer Patients
Author(s) -
KUMAR S.,
COSTELLO C. B.,
GLASHAN R. W.,
BJÖRKLUND B.
Publication year - 1981
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1981.tb03264.x
Subject(s) - urine , bladder cancer , radioimmunoassay , urinary system , medicine , urinary bladder , antigen , urology , cancer , significant difference , clinical significance , pathology , gastroenterology , immunology
Summary— A 2‐stage study has been carried out to evaluate the usefulness of urinary tissue polypeptide antigen (TPA) levels in patients with bladder cancer as an adjunct to the routine procedures for detection of bladder tumours. Two‐hour urine samples were collected from 83 bladder cancer patients and normal individuals for the first part of the study, 24‐h samples from 54 patients and normal individuals for the second part. Urinary TPA was determined using radio immunoassay. In 2‐h samples there was no significant difference in the amounts of TPA/I in any of the groups. In contrast, the TPA results of 24‐h urine samples (n = 54) were markedly different from 2‐h samples and the former correlated very well with the presence or absence of bladder cancer. A reason for this difference may be circadian rhythm effects