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The Early Changes in the Development of Bladder Cancer in Patients Exposed to Known Industrial Carcinogens
Author(s) -
GLASHAN R. W.,
WIJESINGHE D. P.,
RILEY A.
Publication year - 1981
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1981.tb03263.x
Subject(s) - exfoliative cytology , carcinogen , dysplasia , bladder cancer , carcinoma in situ , medicine , basement membrane , urine , cytology , pathology , stage (stratigraphy) , urine cytology , carcinoma , cancer , urology , biology , paleontology , genetics
Summary— In the Huddersfield district many people have been exposed to industrial carcinogens as a result of their occupation. An exfoliative urine cytology screening programme has been in operation for many years so that patients with the early changes associated with these carcinogens are referred for urological investigation at a very early stage in the disease. A description of the development of urothelial dysplasia, carcinoma in situ and transitional cell carcinoma is presented with particular reference to the urine cytology, histological features of mucosal biopsies and cystoscopic appearances of the bladder. Changes in the collagen fibres in the basement membrane are also described.