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The Value of lntravesical Prostaglandin E 2 and F 2α in Women with Abnormalities of Bladder Emptying
Author(s) -
DELAERE K. P. J.,
THOMAS C. M. G.,
MOONEN W. A.,
DEBRUYNE F. M. J.
Publication year - 1981
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1981.tb03183.x
Subject(s) - medicine , urology , residual urine , urine , alpha (finance) , prostaglandin , prostaglandin e2 , residual volume , surgery , internal consistency , prostate , lung volumes , cancer , lung , patient satisfaction
Summary— A clinical study of intravesical prostaglandin E 2 (PGE 2 ) and F 2 α(PGF 2 α) in the treatment of 1 3 female patients with difficulties in emptying their bladder is reported. Urodynamic investigations were performed before and after instillation of the drug. Although 3 patients had some reduction in residual urine volume, the remainder showed no obvious change and no patient experienced subjective improvement. In 6 patients, biopsies of the vesical mucosa were taken before and after instillation in order to measure the uptake of prostaglandin by the mucosa, but no conclusions could be drawn from these measurements. Although prostaglandins are known to have contractile effects on the detrusor muscle, the results of this study suggest that intravesical PGE 2 and PGF 2 α have no therapeutic value in the treatment of voiding dysfunction and residual urine.