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Suppressive Effects of Surgical Stress on Circulating Androgens During and After Prostatectomy
Author(s) -
GHANADIAN R.,
PUAH C. M.,
WILLIAMS GORDON,
SHAH P. J. R.,
McWHlNNEY N.
Publication year - 1981
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1981.tb03155.x
Subject(s) - dihydrotestosterone , medicine , urology , testosterone (patch) , prostatectomy , muscle hypertrophy , androgen , endocrinology , hormone , prostate , cancer
SUMMARY— Changes in circulating testosterone (T) and dihydrotestosterone (DHT) levels were investigated 2 days before and 2, 7, 30 and 60 days after retropubic prostatectomy in 28 patients with benign prostatic hypertrophy. Following operation the concentrations of both steroids declined and reached minimal levels 2 days after surgery. One month post operatively testosterone had recovered to its pre operative value, whilst the recovery of dihydrotestosterone to its pre operative level required a minimum period of 2 months. These data indicate the need for careful interpretation of any androgen measurement following surgery.