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The Effect of Exogenous Prostaglandins F 2α and E 2 and lndomethacin on Micturition
Author(s) -
KHALAF I. M.,
GHONEIM M. A.,
ELHlLALl M. M.
Publication year - 1981
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1981.tb03123.x
Subject(s) - urination , prostaglandin f , chemistry , prostaglandin , endocrinology , biology , urinary system
SUMMARY— The influence of exogenous infusion of prostaglandins (PGs) of the F 2α and E 2 series and of indomethacin on micturition cycles was investigated in 30 anaesthetised female dogs. In 30 other animals, urethrovesical disconnection was performed to study the action of PGs and of indomethacin without the muscle continuity factors. In the intact animal model during vesical distension, PGE l produced a significant urethral pressure drop and a dose‐dependent reduction in the threshold micturition volume. PGF 2α produced a significant urethral pressure rise. At doses higher than 0.3 μg/kg, PGF 2α reduced the threshold micturition volume. On the other hand, indomethacin significantly increased the threshold micturition volume and reduced the maximum intravesical pressure. In the disconnected model, PGE 2 produced a dose‐dependent decrease in the resting urethral pressure and hardly affected the intravesical pressure; PGF 2α produced a dose‐dependent increase in both urethral and intravesical pressures. Thus it is suggested that endogenous PG release during vesical distension could play a facilitatory role in micturition.