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Total and SHBG‐bound Testosterone and 5α‐Dihydrotestosterone Serum Concentrations in Normal Elderly Men and Patients with Benign Prostatic Hypertrophy Before and After Removal of the Adenoma
Author(s) -
LUKKARINEN O.
Publication year - 1980
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1980.tb03063.x
Subject(s) - dihydrotestosterone , sex hormone binding globulin , testosterone (patch) , endocrinology , medicine , androgen , muscle hypertrophy , hormone
Summary— Serum testosterone, 5α‐dihydrotestosterone and their binding by sex hormone binding globulin (SHBG) were quantified in 10 patients with prostatic hypertrophy, before and after retropubic prostatectomy, and in an age‐matched control group. Testosterone was significantly higher in the sera of the BPH patients. The SHBG‐bound testosterone and 5α‐dihydrotestosterone were identical in both groups, but the fraction of testosterone and 5α‐dihydrotestosterone not bound to SHBG was higher in the group with BPH. Therefore patients with prostatic hypertrophy are exposed to increased androgen action. Prostatectomy did not lead to significant changes in serum testosterone, 5α‐dihydrotestosterone or their binding to SHBG.