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Urinary Hydroxyproline Excretion in Carcinoma of the Prostate. A Comparison of 4 Different Modes of Assessment and its Role as a Marker
Author(s) -
MUNDY A. R.
Publication year - 1979
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1979.tb03604.x
Subject(s) - hydroxyproline , urine , creatinine , excretion , morning , urinary system , medicine , urology , urine sample , endocrinology
Summary— Urinary hydroxyproline (HP) excretion has been estimated without prior dietary restriction in 33 patients with carcinoma of the prostate and expressed as either 24‐h HP output or as the hydroxyproline/creatinine (HP/Cr) ratio in a 24‐h urine sample, an early morning urine sample or a spot urine sample. The early morning urine hydroxyproline/creatinine ratio (EMU HP/Cr) appears to be the most accurate and avoids the disadvantages of formal dietary restriction and prolonged urine collection. The rest is useful in monitoring the response to treatment of a patient with bony metastatic disease and relapse of a patient when his tumour ceases to be hormone sensitive. Furthermore, changes in EMU HP/Cr occur earlier than changes in other clinical or investigative variables, giving the test predictive value.