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A Comparison between Propantheline and Imipramine on Bladder and Salivary Gland Function
Author(s) -
TULLOCH A. G. S.,
CREED K. E.
Publication year - 1979
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1979.tb02886.x
Subject(s) - imipramine , anticholinergic , stimulation , medicine , endocrinology , saliva , anticholinergic agents , pathology , alternative medicine
Summary— The effects of propantheline and imipramine on detrusor function and salivary gland secretion were studied in the dog. Both drugs caused a decrease in the rise of intravesical pressure following pelvic nerve stimulation in the anaesthetised dog. Propantheline had a profound effect on the salivary gland, whereas imipramine had very little effect on the volume of saliva produced after electrical stimulation of the chorda tympani. This suggests that the action of imipramine on the bladder is not anticholinergic. The significance for treatment of detrusor dysfunction is discussed.