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Effects of Therapy with Bendroflumethiazide in Patients with Recurrent Renal Calcium Stones
Author(s) -
BACKMAN U.,
DANIELSON B. G.,
JOHANSSON G.,
LJUNGHALL S.,
WIKSTROM B.
Publication year - 1979
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1979.tb02860.x
Subject(s) - medicine , calcium , urology , pharmacology
Summary— Forty‐four patients with recurrent formation of calcium‐containing renal stones were treated with bendroflumethiazide for at least 2 years. Prior to treatment each patient had formed, on average, one stone per year for 8 years; during treatment only 4 patients formed new stones. A reduction in urinary calcium excretion was seen in almost all patients irrespective of their initial urinary calcium level. The apparent clinical benefit was not related to pre‐treatment urinary electrolyte levels. Side effects were slight: one patient developed symptomatic hyperuricaemia and in one case sustained hypercalcaemia was found. Long‐term treatment with thiazides appears to be a safe and effective method for the prevention of recurrent calcium stones.