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An Experimental Approach to the Optimum Oestrogen Dosage in Prostatic Carcinoma
Author(s) -
SYMES ELIZABETH K.,
MILROY E.
Publication year - 1978
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1978.tb06212.x
Subject(s) - diethylstilbestrol , testosterone (patch) , dihydrotestosterone , prostate , medicine , antiandrogens , endocrinology , hormone , androgen receptor , mechanism of action , androgen , prostate carcinoma , chemistry , in vitro , prostate cancer , cancer , antiandrogen , biochemistry
Summary— The action of diethylstilboestrol on the androgen response mechanism of the human prostate has been examined. A simple in vitro test system that assesses effects on hormone uptake, receptor binding and translocation to the nucleus has been employed. The test has also been modified to study the effect of diethylstilboestrol on the activity of 5α‐reductase, the enzyme responsible for the conversion of testosterone to 5α‐dihydrotestosterone. These results are discussed in relation to the dosage of diethylstilboestrol for treatment of carcinoma of the prostate.