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Inosine: Clinical Results of lschaemic Renal Surgery
Author(s) -
WICKHAM J. E. A.,
FERNANDO A. R.,
HENDRY W. F.,
WATKINSON L. E.,
WHITFIELD H. N.
Publication year - 1978
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1978.tb06192.x
Subject(s) - inosine , perfusion , renal function , creatinine , medicine , kidney , nephrectomy , urology , surgery , anesthesia , adenosine
Summary— Ten patients requiring ischaemic renal surgery for calculus or tumour were operated on with the kidney protected by perfusion with a room temperature solution of inosine. The warm ischaemic times ranged from 35 to 75 min (mean 57.1 min). Post‐operative recovery was uneventful in all patients. No adverse cardiodynamic effects due to inosine were noted. There was only moderate transient depression in renal function as assessed by gamma camera renography and serum creatinine estimations. Three of the 10 patients have now been followed for over a year. The results with inosine perfusion are comparable to those obtained with hypothermic protection.