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Clinical and Experimental Studies on the Action of Prostaglandins and their Synthesis Inhibitors on Detrusor Muscle in vitro and in vivo
Author(s) -
BULTITUDE M. I.,
HILLS N. H.,
SHUTTLEWORTH K. E. D.
Publication year - 1976
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1976.tb06711.x
Subject(s) - acetylcholine , in vivo , detrusor muscle , prostaglandin , in vitro , smooth muscle , chemistry , pharmacology , prostaglandin e2 , endocrinology , medicine , biology , biochemistry , microbiology and biotechnology
Summary Experiments on muscle strips have shown that prostaglandin is naturally produced by the detrusor, and acts to increase the tone and spontaneous activity. An intimate relation between acetylcholine and prostaglandin has been demonstrated. Therapeutic application of prostaglandins has been successful in the treatment of chronic retention in women. Upjohn Limited kindly supplied the prostaglandin E 2 . This work was supported by a grant from the Endowment Fund of St Thomas's Hospital, and the muscle strip experiments were carried out in the Department of Pharmacology.