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Chronic Bacterial Prostatitis: New Therapeutic Aspects
Author(s) -
PFAU A.,
SACKS T.
Publication year - 1976
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1976.tb03011.x
Subject(s) - prostatitis , urinary system , prostate , medicine , drug , lower urinary tract symptoms , urology , pharmacology , cancer
In 1968, Meares and Stamey stated that, in the absence of any other pathology, chronic persistence of Gram‐negative entero‐bacteria in the prostate is the commonest cause of relapsing urinary tract infections in males. In the same year, Winningham, Nemoy and Stamey (1968) showed that most of the antibacterial drugs, which are effective in urinary tract infections, are ineffective in curing infections of the prostate gland because of the difficulty with which they cross the epithelial membrane of this gland. The same study suggested that an effective antibacterial drug, able to cross the barrier of the prostatic epithelial membrane and reach therapeutic concentrations in the prostate, should be a lipid soluble base with a high pKa and active against Gram‐negative bacteria at the prostatic pH. Trimethoprim was presented as such a drug, effective in chronic bacterial prostatitis (Reeves and Ghilchik, 1970; Carroll et al. , 1971). Only a few well‐documented cases of chronic bacterial prostatitis have been publishedto date (Meares and Stamey, 1968; Stamey, 1972; Meares, 1973; Meares, 1975). The purpose of this paper is to describe our experience with this entity and to discuss its clinical and therapeutic aspects.