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IgG Catabolism in Anephric Patients
Author(s) -
SOUHAMI R. L.,
BAKER L. R. I.,
PLATT H. S.,
FELDMAN T.
Publication year - 1975
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1975.tb04016.x
Subject(s) - catabolism , sephadex , dialysis , chronic renal failure , endocrinology , medicine , chemistry , kidney , chromatography , biochemistry , metabolism , enzyme
Summary The catabolism of purified human 125 I labelled IgG has been studied in patients with chronic renal failure, both nephrectomised and non‐nephrectomised, on intermittent haemodialysis. In all patients the T1/2 of IgG was the same as in normal controls, and using chromatographic separation on Sephadex G200, there was no evidence of alteration of molecular size as a result of dialysis. The results do not support the notion that the kidney is an important site of IgG catabolism in humans.