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Ampicillin, Carbenicillin Indanyl Ester, and Nifuratel in the Treatment of Urinary Infection in Domiciliary Practice
Author(s) -
Davies B. I.,
Mummery R. V.,
Brumfitt W.
Publication year - 1975
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1975.tb03978.x
Subject(s) - carbenicillin , ampicillin , antimicrobial , medicine , urinary system , penicillin , drug , bacteriuria , urine , antibiotics , pharmacology , microbiology and biotechnology , biology
Summary A total of 120 patients, including 53 pregnant women with significant bacteriuria, received 163 7‐day courses of oral antimicrobial agents allocated in a randomised manner. The cure rates after 6 weeks' follow‐up ranged from 73% to 86%, and there was no statistical difference between preparations of ampicillin, carbenicillin indanyl ester, and 2 different formulations of nifuratel. Side‐effects occurred in 30% to 40% of the courses of penicillin drugs, but in under 15% of the course of nifuratel. It is concluded that the new oral preparation of carbenicillin is a useful addition to the list of antimicrobial agents which are effective in the treatment of urinary infections in domiciliary patients. Furthermore, nifuratel has been confirmed as a highly active non‐toxic drug which is valuable in the treatment of urinary infections.