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The Relationship of the Urinary Cations, Calcium, Magnesium, Sodium and Potassium, in Patients with Renal Calculi
Author(s) -
WELSHMAN S. G.,
MCGEOWN M. G.
Publication year - 1975
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1975.tb03956.x
Subject(s) - potassium , calcium , magnesium , chemistry , creatinine , sodium , urine , medicine , endocrinology , urinary calcium , excretion , biochemistry , organic chemistry
Summary Calcium, magnesium, sodium and potassium were estimated in the 24‐hour urine collections of 101 idiopathic male stone‐formers, 89 male patient controls and 59 young male adult controls. The results were calculated in terms of 24‐hour volume and 1 g of creatinine. The concentrations of the 4 cations, relative to a gram of creatinine, were also determined in the early‐morning urines of 41 male stone‐formers and 43 young male adult controls. No difference was observed in the 24‐hour excretion of calcium, magnesium and sodium between the stone‐formers and controls. The mean daily potassium excretion, however, was significantly reduced in the urine of stone‐formers. The linear regression equations were calculated for calcium on magnesium, calcium on sodium, and calcium on potassium, using the 24‐hour excretion values of these cations. Only the calcium on potassium line of stone‐formers was significantly different from that of the normal subjects. A significant increase by stone‐formers in the urinary calcium concentration of their early‐morning specimens was found. The high concentration of urinary calcium in overnight urines of stone‐formers combined with a low magnesium concentration might possibly contribute to the development of renal stone disease.