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A Double Blind Trial of a Polyene Macrolide‐ Nystatin‐in the Treatment of Benign Prostatic Hyperplasia in Man
Author(s) -
BOURKE J. B.,
GRIFFIN J. P.,
THEODORIDES P.
Publication year - 1974
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1974.tb10185.x
Subject(s) - nystatin , polyene , hyperplasia , medicine , double blind , placebo , prostate , dermatology , urology , gastroenterology , chemistry , pathology , cancer , biochemistry , antifungal , alternative medicine
Summary Gordon and Schaffner (1968) showed that anti‐fungal drugs of the polyene macrolide group caused a reduction in volume of the hyperplastic prostate of aged dogs. It was, therefore, decided to investigate the effect of nystatin in patients with benign prostatic hyperplasia. In a double blind trial of 6 weeks' duration nystatin in doses of 500,000 units 8–hourly when taken orally was without effect when compared with a placebo.