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The Role of Some Tryptophan Metabolites in Certain Diseases of the Genito‐Urinary System 1
Author(s) -
ALHADITHI NAJIM A.
Publication year - 1974
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1974.tb03835.x
Subject(s) - xanthurenic acid , anthranilic acid , excretion , kynurenine , tryptophan , endocrinology , urine , kynurenine pathway , medicine , chemistry , physiology , biochemistry , amino acid
Summary Thin‐layer chromatography (qualitative and quantitative) was used to examine the excretion of 4 tryptophan metabolites, kynurenine and 3‐hydroxy‐kynurenine, anthranilic acid and xanthurenic acid. The control group showed a small range of variation from day to day and from person to person, except for one who was on the contraceptive pill. She showed a marked increase in the amount of the metabolites excreted. The excretion was increased in a proportion of the kidney and bladder neoplasm patients. In the calculus cases, 2 showed a marked rise, while of the patients with prostatic hyperplasia 1 had a very high excretion as did 1 of the cases of retroperitoneal fibrosis. High excretion can occur in a variety of conditions but as yet is no aid to diagnosis.