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Carcinoma of the Urinary Tract and Urinary Retention in Uganda
Author(s) -
ANTHONY P. P.
Publication year - 1974
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1974.tb03744.x
Subject(s) - urinary system , medicine , metaplasia , incidence (geometry) , carcinoma , urinary bladder , etiology , basal cell , pathology , urology , gastroenterology , optics , physics
SUMMARY Carcinoma of the urinary tract in Uganda shows some unusual features. Squamous cell carcinoma is the predominant histological type. This is associated not with urinary schistosomiasis, which only occurs in one small area of the country, but with longstanding posterior urethral strictures of gonococcal origin. This association is found in both bladder and urethral carcinomas, the relative frequency of the latter being unusually high. Possible aetiological factors include dietary overload with tryptophan and increased beta‐glucuronidase activity. The presence of a stricture is likely to have an enhancing effect on carcinogenesis and is the major factor in producing a high incidence of squamous cell growths through urinary stasis, infection and metaplasia.