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Urological Complications of Cyclophosphamide
Author(s) -
WATSON N. A.,
NOTLEY R. G.
Publication year - 1973
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1973.tb12230.x
Subject(s) - cyclophosphamide , medicine , asymptomatic , hemorrhagic cystitis , reflux , fibrosis , urinary system , retroperitoneal fibrosis , urology , surgery , chemotherapy , disease
Summary Cyclophosphamide may cause fibrosis of the bladder in a significant number of patients. Most will be asymptomatic but the fibrosis can lead to reflux. Cystitis, frequently haemorrhagic, occurs in 10–40 % of patients and usually responds to withdrawal of the drug. Active measures to stop the bleeding may be required. Bleeding from the upper urinary tract is rare. The association of bladder tumours with cyclophosphamide cystitis has been reported in only 2 cases.