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Treatment of Patients with Calcium‐containing Renal Stones with Cellulose Phosphate
Author(s) -
PIETREK JERZY,
KOKOT FRANCISZEK
Publication year - 1973
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1973.tb12130.x
Subject(s) - hypercalcaemia , hypercalciuria , nephrocalcinosis , calcium , medicine , magnesium , renal function , endocrinology , gastroenterology , calcium oxalate , urology , chemistry , kidney , organic chemistry
Summary Sodium cellulose phosphate (SCP) was administered in a dose of 15 g per day to 2 patients with hyperoxaluria and to 11 stone‐formers (8 with and 3 without hypercalciuria). Urinary calcium excretion decreased in all patients up to 50 per cent or less of basal values. Attacks of renal colic and the passage of small stones became less frequent. In the course of treatment a trend towards lower, although statistically not significantly lower, levels of serum magnesium, iron, copper and zinc concentrations was observed. In 2 patients with primary hyperparathyroidism symptomatic improvement of hypercalcaemia was observed. No subjective side‐effects were noted; renal and liver function tests, blood cells and serum electrolytes did not show any change in the course of prolonged treatment with SCP. Four out of 10 patients exhibited lower levels of oxaluria after treatment. An increase of oxaluria was found mainly in those patients in whom a fall of magnesium levels developed in the course of treatment.