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Treatment of Pseudomonas Urinary Infections with Oral Carbenicillin
Author(s) -
BERRILL W. T.,
MASKELL ROSALIND,
PEAD LINDA,
POLAK A.
Publication year - 1973
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1973.tb06823.x
Subject(s) - carbenicillin , proteus , urinary system , medicine , pseudomonas , urine , creatinine , antibiotics , urology , microbiology and biotechnology , gentamicin , biology , bacteria , escherichia coli , biochemistry , genetics , gene
Summary A trial of oral carbenicillin for the treatment of Pseudomonas urinary infections in 8 patients is reported. Pseudomonas was eradicated in 6 patients, but recurred in 1. Treatment had to be curtailed in the remaining 2, who developed rashes. In a pharmacokinetic study of 10 patients with varying degrees of renal insufficiency it was shown that levels of carbenicillin likely to be adequate for the treatment of Pseudomonas urinary infections were attained in patients with creatinine clearances of over 6 ml/min. With clearances below this level there was evidence that absorption was impaired, and adequate urine levels were not achieved. It is suggested that the use of oral carbenicillin should be restricted to the treatment of Pseudomonas and indole‐positive Proteus infections confined to the urinary tract.