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ACUTE RENAL FAILURE FOLLOWING ANALGESIC OVERDOSE IN G6PD DEFICIENCY
Author(s) -
Brown C. B.,
McMillan Judith M.,
Bateman C. J. T.,
Cattell W. R.
Publication year - 1972
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1972.tb10059.x
Subject(s) - medicine , renal papillary necrosis , acute tubular necrosis , pathogenesis , peritoneal dialysis , analgesic , dialysis , acute kidney injury , anesthesia , gastroenterology , kidney
SUMMARY A case is described of a West‐Indian Negro male with glucose‐6‐phosphate dehydrogenase deficiency who developed acute intravascular hæmolysis, renal failure and reversible sideroblastic anæmia, following an overdose of Codeine Compound tablets. The renal failure was successfully managed by peritoneal dialysis. Generalised renal papillary necrosis was found on pyelography 6 months later and it is suggested that this may have been conditioned by and occurred at the time of the acute renal failure. Problems regarding the diagnosis of G6PD deficiency following acute hæmolysis are discussed and the possible pathogenesis of the transient sideroblastic anæmia observed in the patient is considered.