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URINARY ORGANIC ACIDS FOUND IN B 6 ‐DEFICIENT RATS AND CALCIUM OXALATE CALCULUS PATIENTS 1
Author(s) -
ZINSSER HANS H.,
STERN FREDERICO,
MARSHALL SARA,
KARP FRIEDA,
SENECA ELIZABETH,
GURSEL EROL
Publication year - 1971
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1971.tb10038.x
Subject(s) - oxalate , tyrosine , calcium oxalate , chemistry , oxalic acid , calcium , urinary system , endocrinology , amino acid , metabolism , medicine , citric acid , phenylalanine , biochemistry , inorganic chemistry , organic chemistry
SUMMARY1 B 6 ‐deficient rats and calcium oxalate stone‐forming patients share several metabolic abnormalities. 2 In our experiments, evidence for folic acid deficiency in the stone patients is strong, and some evidence exists in B 6 –deficient rats as well. 3 Susceptibility to overload of the acetyl coenzyme A system is high in both. 4 Sources of oxalic acid probably include aromatic amino acid derivatives with a 3 carbon side chain, whose metabolism is blocked by tyrosine, and whose dependence on the acetyl coenzyme A system is shown by the simultaneous drop in oxalate, hippurate, α‐ketoglutarate and citric acids. That hydroxy‐proline is a major source seems a probable explanation for changes in oxalate excretion with stress. 5 Both B 6 –deficient rats and hyperoxaluric patients respond to tyrosine administration by a drop in urinary oxalate.