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THE USE OF LASIX (FRUSEMIDE) IN THE PREVENTION OF URINARY INFECTION FOLLOWING PROSTATECTOMY
Author(s) -
Essenhigh D. M. M.,
Clayton C. B.,
Taha M. A.
Publication year - 1970
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1970.tb04482.x
Subject(s) - medicine , urine , urology , catheter , indwelling catheter , urine flow rate , urinary system , urinary catheterization , surgery , prostatectomy , prostate , cancer
SUMMARY In 50 patients undergoing prostatectomy Lasix was administered until the catheters were removed. It was found that a urinary flow rate in excess of 200 ml./hr. could safely be maintained day and night. This flow rate is substantially greater than that theoretically necessary to maintain sterility of the bladder contents. The urine was infected on removal of the catheter in 4 patients (7.9 per cent. in 51 operations), there being an adequate cause for infection in 3 of these patients. It was possible to sterilise the urine pre‐operatively using Lasix alone in 2 patients who had suprapubic catheters, and another 3 patients whose urine was infected pre‐operatively were rendered sterile over the period of catheterisation using Lasix alone. Bladder drainage in the presence of an indwelling catheter was investigated using radioactive Hippuran. Clearance time was shown to be exponential in 15 out of 18 patients, but the observed halving time was found to be considerably greater than the theoretical halving time. The reason for this has not been found: it is suggested that bladder drainage in these circumstances may be more complex than a simple mathematical model would suggest.