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THE EFFECT OF ŒSTROGEN UPON ASCENDING URINARY TRACT INFECTION IN RATS
Author(s) -
Corriere Joseph N.,
Murphy John J.
Publication year - 1968
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1968.tb09891.x
Subject(s) - urinary system , hydronephrosis , bacteriuria , pregnancy , urology , medicine , urinary bladder , inoculation , bladder stones , physiology , biology , pathology , genetics
SUMMARY Rats were inoculated transurethrally with E. coli 14 days after treatment with ostrogen, 35 days after treatment with ostrogen, or without ostrogen therapy. The ostrogen produced gross hydronephrosis in 82 per cent, of the animais after 28 days of therapy and 100 per cent, by day 63. The animais inoculated 14 days after ostrogen treatment had begun handled their infections as well as the controls, but those that were treated for 35 days developed persistent high colony counts in the bladder and kidneys. Histological changes of the urinary tract produced by ostrogen therapy and possible correlations to the persistent bacteriuria of pregnancy are discussed.