A METHOD OF PRODUCING EXPERIMENTAL URæMIA IN THE RABBIT WITH SOME OBSERVATIONS ON THE INFLUENCE OF URæMIA ON PERITONEAL HEALING

SUMMARY A one–stage retroperitoneal method of producing acute transient experimental uræia is described. After defects in the peritoneum have been fashioned, the uræmic state delays the formation of new peritoneum and depresses the production of collagen. It would be advisable to include uræmia amongst other general factors when future studies of wound disruption are contemplated. The majority of this work was performed in the Surgical Unit Laboratories, Westminster Hospital. We would like to thank Professor D. Slome for providing additional facilities at the Department of Physiology, Royal College of Surgeons. We are grateful to Dr Klaus Lewin for assistance with the histology and photographs.