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URINARY ENZYMES IN BENIGN AND MALIGNANT URINARY TRACT DISORDERS:ALKALINE PHOSPHATASE AND LACTIC ACID DEHYDROGENASE 1
Author(s) -
GAULT M. HENRY,
OLIVER JOHN A.,
LANG CELLA,
ASGHAR M. I.,
LEVY S. W.
Publication year - 1967
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1967.tb09809.x
Subject(s) - urinary system , urine , alkaline phosphatase , medicine , lactic acid , enzyme , lactic dehydrogenase , urology , kidney , acid phosphatase , endocrinology , chemistry , biology , biochemistry , bacteria , genetics
SUMMARY The normal range of values for urinary alkaline phosphatase by a partially automated method and for urine lactic–acid dehydrogenase activity by a colorimetric method was established and was compared with values obtained in association with neoplasms of the urinary tract, extra–urinary neoplasms, and with other disorders of the genito–urinary tract. The findings do not indicate that such assays constitute an important addition to conventional methods for the diagnosis of kidney or bladder neoplasms, although urinary enzyme activity was increased in the presence of normal urine analysis in some patients. Urinary alkaline phosphatase activity may be increased in cases of malignant disease not involving the urinary tract and also in association with a major elevation of activity in the serum. Problems associated with the assay of urinary enzymes and the interpretation of the values obtained are discussed. We are indebted to Miss A. Illing for technical assistance.