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CYCLOPHOSPHAMIDE IN RENAL HOMOTRANSPLANTATION 1
Author(s) -
PARSONS F. M.,
Fox M.,
ANDERSON C. K.,
MARKLAND C.,
CLARK P. B.,
RAPER F. P.
Publication year - 1966
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1966.tb09776.x
Subject(s) - cyclophosphamide , prednisone , medicine , kidney , kidney transplantation , urology , transplanted kidney , transplantation , chemotherapy
SUMMARY 1. The use of cyclophosphamide as an immunosuppressive drug was assessed in eight human renal transplantations. 2. The classical immunological response was suppressed but all cases that survived longer than two weeks developed vascular lesions in the transplanted kidney. 3. Although the addition of prednisone led to some regression of the vascular lesions in one case, we were unable to control the dose of cyclophosphamide safely immediately after transplantation. 4. As a result of the above experiences, the use of cyclophosphamide as an immunosuppressive agent in renal homotransplantation is not advocated.