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COLISTIN IN PSEUDOMONAS PYOCYANEA INFECTIONS AND ITS EFFECT ON RENAL FUNCTION
Author(s) -
BRUMFITT W.,
BLACK M.,
WILLIAMS J. D.
Publication year - 1966
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1966.tb09743.x
Subject(s) - colistin , antibiotics , medicine , renal function , nephrotoxicity , urinary system , urine , creatinine , kidney , microbiology and biotechnology , biology
SUMMARY Estimation of blood levels after administration of 120 mg. colistin sulphomethate sodium revealed concentrations lower than those previously reported in this country. However, the blood levels obtained inhibited the growth of many strains of Ps. pyocyanea and Esch. coli. Colistin S.M. is mainly excreted in the urine where very high concentrations were found. Twenty–one patients with urinary infection due to Ps. pyocyanea were treated with colistin S.M. and eradication was obtained in thirteen (62 per cent.) compared with five out of seventeen patients (29 per cent.) who were given other antibiotics. Following the administration of colistin S.M. to volunteers, a fall in creatinine clearance was observed in every case, and a transient rise in blood urea was also noted. This effect was not observed in patients with urinary tract infection and it was thought likely that any decrease in renal efficiency due to the colistin S.M. was balanced by the increase in efficiency resulting from control of the infection. Colistin S.M. is of value, therefore, in treatment of Ps. pyocyanea infections and Esch. coli infections resistant to the commoner antibiotics, but the nephrotoxic effect must be borne in mind especially where impaired renal function is suspected. The changes in renal function which we observed to follow the administration of colistin S.M. appear to be reversible. We wish to thank Mr J. de Louvois for his skilled technical assistance and Drs J. J. Brown and B. J. Houghton for advice on the renal function studies. Dr A. J. Martin of Pharmax Ltd. kindly supplied some of the Colomycin used in this investigation.