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OCTOCALCIUM PHOSPHATE: THE PHASE GOVERNING THE SOLUBILITY EQUILIBRIUM IN APATITIC CALCULI
Author(s) -
Macgregor J.,
Robertson W. G.,
Nordin B. E. C.
Publication year - 1965
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1965.tb09640.x
Subject(s) - solubility equilibrium , phosphate , solubility , chemistry , stoichiometry , calcium , phase (matter) , phase equilibrium , chemical equilibrium , ion , inorganic chemistry , mineralogy , biochemistry , organic chemistry
SUMMARY1 Powdered apatitic renal calculi have been allowed to come into equilibrium with buffers in the p H range 7 to 8. 2 The ion products for the commoner calcium phosphate salts have been calculated and related to p H at equilibrium. 3 Only the p K of the ion product [Ca ++ ] 8 [HPO 4 = ] 2 [PO 4 ≡ ] 6 is independent of p H 4 Determination of the stoichiometry of the exchange reaction at equilibrium suggests a Ca: P of 7.9:6. 5 It is suggested that, quite apart from the apparent average composition of apatitic renal calculi, the phase on the crystal surfaces determining the physico‐chemical characteristics of the equilibrium is octocalcium phosphate. 6 It is suggested that the critical phase governing the solubility of calcium phosphate in urine in vivo may be octocalcium phosphate.