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THE CARCINOGENIC AND CO‐CARCINOGENIC EFFECTS OF PARAFFIN WAX PELLETS AND GLASS BEADS IN THE MOUSE BLADDER
Author(s) -
Ball JudithK.,
Field WinifredE. H.,
Roe F. J. C.,
Walters Margaret
Publication year - 1964
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1964.tb09505.x
Subject(s) - wax , medicine , bladder cancer , gratitude , pellets , cancer , psychology , materials science , composite material , social psychology
SUMMARY1 Bladder tumours arose in mice in response to the presence in the bladder, over a prolonged period, of paraffin wax pellets or glass beads. 2 In the case of implanted glass beads the administration of two doses of urethane by stomach tube early in the experiment increased the incidence of bladder tumours, the increase being statistically significant. 3 The implications of these findings are briefly discussed.We gratefully express our thanks to Miss Penelope Bell for her kind assistance in looking after the animals during this experiment, and to Mr J. Everett for measuring the lead content of the glass beads. We acknowledge our gratitude to the Medical Research Council who partly financed this work out of the money derived from the Tobacco Manufacturers Benefaction, and to Professor Haddow for granting us laboratory space at the Pollards Wood Research Station of the Institute of Cancer Research; also to the British Empire Cancer Campaign for financial support, both through a block grant to the London Hospital Medical College, and jointly with the National Cancer Institute of Canada for a Canadian‐British Exchange Fellowship to one of us (J. K. B.).