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CYCLOSERINE IN THE TREATMENT OF INFECTION OF THE URINARY TRACT
Author(s) -
SYME J.,
SLEIGH J. D.,
RICHARDSON J. E.,
MURDOCH J. McC.
Publication year - 1961
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1961.tb11612.x
Subject(s) - urinary system , cycloserine , medicine , proteus , urine , antibiotics , urology , intensive care medicine , physiology , surgery , pharmacology , microbiology and biotechnology , biology , escherichia coli , biochemistry , gene
SUMMARY Forty patients with urinary tract infections were treated with cycloserine in doses of 250 mg. eight‐hourly for fourteen days. Whenever possible, bacteriological, biochemical, and radiological investigations were carried out before treatment. Thirty‐six patients (90 per cent.) had sterile urine seventy‐two hours after treatment; the results of follow‐up studies are presented. Serious toxic effects were encountered in two patients (5 per cent.). Cycloserine is a valuable drug in the treatment of urinary tract infections which have failed to respond to the more commonly used drugs. It is especially likely to succeed where the causative organism is E. coli ; less so in the case of B. proteus. Serious toxic effects are unlikely to arise with a dose of 250 mg. eight‐hourly: such treatment should be continued for at least fourteen days, fluid intake being restricted during this time. The risks of toxic effects will be minimised by biochemical assessment of renal function before, and estimation of plasma levels of the antibiotic during treatment. As with any other antibacterial agent, drainage defects of the urinary tract should be sought and, if possible, corrected before treatment. Clinical and bacteriological follow‐up should be prolonged. We wish to thank Messrs Eli Lilly and Company Limited for a generous grant to defray laboratory expenses and for supplies of cycloserine. Dr S. C. Frazer kindly carried out the chemical estimations of cycloserine. We are indebted to Mr W. S. Tulloch for carrying out the surgical urology, and to Professor R. J. Kellar for referring many of the patients from his department.