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SOME OBSERVATIONS ON THE DISTRIBUTION OF RADIOACTIVE ZINC IN PROSTATIC AND OTHER HUMAN TISSUES
Author(s) -
Daniel Owen,
Haddad Farid,
Prout George,
Whitmore Willet F.
Publication year - 1956
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1956.tb04770.x
Subject(s) - zinc , malignant disease , liver tissue , tissue distribution , prostate , chemistry , human blood , radiochemistry , cancer , medicine , pathology , physiology , organic chemistry
SUMMARY Intravenous injections of 65 Zn containing 50 to 100 μc. of radioactivity and 50 to 100 μg. of carrier zinc have been given to fifteen patients suffering from various forms of malignant disease and the radioactive content of blood and other tissues estimated twenty to ninety‐six hours later. Results expressed as 65 Zn organ/blood ratios have been compared with zinc organ/blood ratios calculated from data reported by other workers from chemical determinations on similar tissues. The radioactive and chemical ratios are generally of the same order with the exception of muscle which had a much lower, and liver and certain samples of carcinomatous prostatic tissue which had a much higher 65 Zn ratio than Zn ratio. Carcinomatous prostatic tissue from one patient had a 65 Zn tissue/blood ratio of 40, which is twice as much as the highest ratio found in any other tissue. This study was supported by the New York Cancer Committee and the Lerner Fund. The writers gratefully acknowledge the assistance of Miss Eva Simmel in preparing the autoradiographs.