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THE URINARY CITRATE EXCRETION IN PATIENTS WITH RENAL CALCULI
Author(s) -
Conway Nancy S.,
Maitland A. Ian L.,
Rennie J. Basil
Publication year - 1949
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1949.tb10749.x
Subject(s) - urinary system , urine , kidney , excretion , chemistry , medicine , endocrinology , urology
Summary It has been suggested that an important factor in the formation of renal calculi is a deficiency of citrate excretion by the kidney. This we have failed to confirm and consider rather that any gross diminution of urinary citrate is due simply to infection of the urinary tract. The proof of this is as follows:‐ 1. In seven patients with calculi and a sterile tract the average citrate content of the urine was comparable with that found in controls. 2. Seven patients with calculi, associated with infection, were all found to have less citrate in their urine than normals. 3. Experiments in vitro confirmed that in this latter group citrate was destroyed particularly by E. colz, although with Kosers medium this splitting action was not detectable.