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The effects of ketamine‐midazolam anesthesia on intraocular pressure in clinically normal dogs
Author(s) -
Ghaffari Masoud Selk,
Rezaei Mohammad Ali,
Mirani Amir Hessam,
Khorami Nargess
Publication year - 2010
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/j.1463-5224.2010.00762.x
Subject(s) - ketamine , midazolam , saline , anesthesia , medicine , significant difference , intraocular pressure , surgery , sedation
Objective To determine the effects of intravenous ketamine‐midazolam anesthesia on intraocular pressure (IOP) in ocular normotensive dogs. Animals Thirteen adult mixed‐breed dogs. Procedures Dogs were randomly assigned to treatment ( n = 7) and control ( n = 6) groups. Dogs in the treatment group received intravenous ketamine 15 mg/kg and midazolam 0.2 mg/kg and dogs in the control group received intravenous saline. The time of intravenous drug injection was recorded (T 0 ). Measurements of IOP were then repeated 5 min (T 5 ) and 20 min (T 20 ) following the intravenous administration of ketamine‐midazolam combination and saline in both groups. Results Measurements showed normal IOP values in both groups. The mean ± SD baseline IOP values for treatment and control groups were 13.00 ± 1.47 and 10.33 ± 2.20, respectively. For baseline IOP values, there was no significant difference between treatment and control groups ( P = 0.162). In the treatment group, the subsequent post‐treatment mean ± SD values were 15.64 ± 2.17 (5 min), and 14.92 ± 1.98 (20 min). There was no evidence of statistical difference between baseline values and post‐treatment values after treatment with ketamine‐midazolam (P 5 = 0.139; P 20 = 0.442). In control eyes, the mean ± SD values at 5 and 20 min were 10.41 ± 2.01 and 10.16 ± 1.69, respectively. There was no significant difference between baseline values and post‐treatment values in control group (P 5 = 1.000; P 20 = 1.000). Conclusion Ketamine‐midazolam combination has no clinically significant effect on IOP in the dog.