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The use of canine models of inherited retinal degeneration to test novel therapeutic approaches
Author(s) -
Beltran William A.
Publication year - 2009
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/j.1463-5224.2009.00694.x
Subject(s) - blindness , retinal degeneration , neuroprotection , neuroscience , medicine , retinal , genetic enhancement , bioinformatics , biology , gene , ophthalmology , genetics , optometry
Inherited retinal degenerations (RDs) are a common cause of blindness in dogs and in humans. Over the past two decades numerous genes causally associated with these diseases have been identified and several canine models have been used to improve our understanding of the molecular mechanisms of RDs, as well as to test the proof of principle and safety of novel therapies. This review briefly summarizes the drug delivery approaches and therapeutic strategies that have been and are currently tested in dogs, with a particular emphasis on corrective gene therapy, and retinal neuroprotection.