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Histological differences in full‐thickness vs. lamellar corneal pig‐to‐rabbit xenotransplantation
Author(s) -
Oh Joo Youn,
Kim Mee Kum,
Ko Jung Hwa,
Lee Hyun Ju,
Park Chunggyu,
Kim Sang Joon,
Wee Won Ryang,
Lee Jin Hak
Publication year - 2009
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/j.1463-5224.2008.00680.x
Subject(s) - xenotransplantation , cornea , lamellar structure , infiltration (hvac) , pathology , lagomorpha , lamellar granule , medicine , ophthalmology , transplantation , chemistry , surgery , materials science , ultrastructure , composite material , crystallography
To evaluate the differences in graft survival and histopathological characteristics between full‐thickness and lamellar orthotopic corneal xenotransplantation in a pig‐to‐rabbit model, we orthotopically transplanted a full‐thickness or the anterior half of a pig's cornea onto the OD of 16 rabbits. As a result, the median survival were 16.83 and 29.07 days for the full‐thickness and lamellar xenografts, respectively ( P = 0.0005). Histologically, the full‐thickness corneal xenografts had massive infiltration by eosinophils, whereas the lamellar xenografts showed predominantly mononuclear infiltrates ( P < 0.05). Given these preliminary findings, lamellar corneal xenografts in rabbits survived longer than the full‐thickness xenografts and each type of graft demonstrated different rejection mechanisms.