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Inheritance of cataract in the Bichon Frise
Author(s) -
Wallace M. R.,
MacKay E. O.,
Gelatt K. N.,
Andrew Stacy E.
Publication year - 2005
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/j.1463-5224.2005.00359.x
Subject(s) - cataracts , heredity , trait , ophthalmology , inheritance (genetic algorithm) , medicine , autosomal recessive trait , biology , physiology , genetics , gene , computer science , programming language
Objective To determine the mode of inheritance of cataract formation in the Bichon Frise. Materials Thirty‐six closely related Bichon Frise dogs in a pedigree of 61 dogs were examined using slit‐lamp biomicroscopy and indirect ophthalmoscopy over a period of 10 years. Results Of the 61 related dogs, 36 were examined repeatedly. Twelve cataractous dogs were diagnosed (three males and nine females). Cataractous dogs resulted from matings between unaffected parents, and when one parent was cataractous and the other parent was unaffected. Age at onset of cataract formation ranged from 18 to 160 months. Available information suggests that the cataracts are inherited as an autosomal recessive trait. Conclusion Cataracts appear inherited in the Bichon Frise as an autosomal recessive trait. Additional cataract × cataract matings are necessary to confirm the autosomal recessive heredity.