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Effect of orally administered hydrocortisone on intraocular pressure in nonglaucomatous dogs
Author(s) -
Herring Ian P.,
Herring Erin S.,
Ward Daniel L.
Publication year - 2004
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/j.1463-5224.2004.04036.x
Subject(s) - medicine , hydrocortisone , intraocular pressure , placebo , anesthesia , capsule , ophthalmology , botany , alternative medicine , pathology , biology
Abstract Objective To determine the effect of oral hydrocortisone on intraocular pressure (IOP) in ocular normotensive dogs. Animals studied Seventeen ocular normotensive dogs. Procedures Dogs were randomly assigned to treatment ( n = 9) and control ( n = 8) groups. Dogs in the treatment group received hydrocortisone, 3.3 mg/kg PO every 8 h, and dogs in the control group received gelatin capsule placebo PO every 8 h for 5 weeks. Applanation tonometry was performed on both eyes of all dogs prior to treatment and then once weekly for 5 weeks during hydrocortisone treatment. Results No significant effect of treatment was noted for right ( P = 0.1013) or left ( P = 0.1157) eyes during the treatment period, nor was there significant interaction of treatment by week for the right ( P = 0.9456) or left ( P = 0.3577) eyes. A significant rise in IOP over the treatment period was noted in both right ( P < 0.0001) and left ( P = 0.0006) eyes of both groups, but was unrelated to treatment. Conclusion Orally administered hydrocortisone does not significantly increase IOP in nonglaucomatous dogs when administered over a 5‐week period.