Premium
Effect of orally administered hydrocortisone on intraocular pressure in nonglaucomatous dogs
Author(s) -
Herring Ian P.,
Herring Erin S.,
Ward Daniel L.
Publication year - 2004
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/j.1463-5224.2004.04036.x
Subject(s) - medicine , hydrocortisone , intraocular pressure , placebo , anesthesia , capsule , ophthalmology , botany , alternative medicine , pathology , biology
Objective To determine the effect of oral hydrocortisone on intraocular pressure (IOP) in ocular normotensive dogs. Animals studied Seventeen ocular normotensive dogs. Procedures Dogs were randomly assigned to treatment ( n = 9) and control ( n = 8) groups. Dogs in the treatment group received hydrocortisone, 3.3 mg/kg PO every 8 h, and dogs in the control group received gelatin capsule placebo PO every 8 h for 5 weeks. Applanation tonometry was performed on both eyes of all dogs prior to treatment and then once weekly for 5 weeks during hydrocortisone treatment. Results No significant effect of treatment was noted for right ( P = 0.1013) or left ( P = 0.1157) eyes during the treatment period, nor was there significant interaction of treatment by week for the right ( P = 0.9456) or left ( P = 0.3577) eyes. A significant rise in IOP over the treatment period was noted in both right ( P < 0.0001) and left ( P = 0.0006) eyes of both groups, but was unrelated to treatment. Conclusion Orally administered hydrocortisone does not significantly increase IOP in nonglaucomatous dogs when administered over a 5‐week period.