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Incretin and pancreatic hormone secretion in Caucasian non‐diabetic carriers of the TCF7L2 rs7903146 risk T allele
Author(s) -
Færch K.,
Pilgaard K.,
Knop F. K.,
Hansen T.,
Pedersen O.,
Jørgensen T.,
Holst J. J.
Publication year - 2013
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2012.01675.x
Subject(s) - medicine , endocrinology , incretin , tcf7l2 , insulin , glucagon , diabetes mellitus , glucagon like peptide 1 , gastric inhibitory polypeptide , hormone , endogeny , allele , pancreatic hormone , type 2 diabetes , insulin resistance , biology , single nucleotide polymorphism , gene , biochemistry , genotype
We characterised 62 non‐diabetic, middle‐aged, Caucasians with and without the T risk allele of rs7903146 in transcription factor 7‐like 2 ( TCF7L2 ) with regard to secretion of insulin, glucagon, glucose‐dependent insulinotropic polypeptide ( GIP ), glucagon‐like peptide‐1 ( GLP ‐1) as well as insulin sensitivity and endogenous glucose production. All participants had a 3‐h oral glucose tolerance test ( OGTT ), an intravenous glucose tolerance test and a euglycaemic, hyperinsulinaemic clamp. After adjustment for age and sex, risk T allele carriers had higher haemoglobin A1c levels (p = 0.030), reduced first‐phase insulin response (p = 0.048), higher peripheral insulin sensitivity (p = 0.050) and lower fasting GIP concentrations (p = 0.003) than CC allele carriers. The latter was also reflected by lower total GIP secretion during the OGTT (p = 0.018). We found no significant differences in endogenous glucose production, hepatic insulin sensitivity or fasting concentrations of glucose, insulin, glucagon and GLP ‐1 between the groups. The findings suggest that the effect of TCF7L2 on diabetes risk may include reduced secretion of GIP .