Premium
Body mass index and the efficacy of needle‐free jet injection for the administration of rapid‐acting insulin analogs, a post hoc analysis
Author(s) -
Galan B. E.,
Engwerda E. E. C.,
Abbink E. J.,
Tack C. J.
Publication year - 2013
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2012.01666.x
Subject(s) - insulin , body mass index , medicine , waist , endocrinology , confidence interval , lean body mass , body weight
We recently showed in a euglycaemic glucose clamp study among 18 healthy volunteers that using jet injectors rather than conventional pens significantly improved the time‐action profiles of rapid‐acting insulin analogs. Here, we investigated whether such profiles were modified by body mass index ( BMI ) and related weight parameters by comparing insulin administration by jet injection to that by conventional pen in subgroups defined by BMI , waist‐to‐hip ratio, waist circumference and insulin dose. After conventional administration, times to peak insulin levels (T‐ INS max ) occurred 31.1 [95% confidence interval ( CI ) 13.7–48.5] min later and time to maximum glucose requirement (T‐ GIR max ) 56.9 (95% CI 26.6–87.3) min later in more obese ( BMI > 23.6 kg/m 2 ) than in lean subjects ( BMI < 23.6 kg/m 2 ). In contrast, T‐ INS max and T‐ GIR max were similar in subjects with high and low BMI , when insulin was administered by jet injection. We conclude that using jet injection for insulin administration may especially benefit subjects with higher body weight.