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Short‐term glucose variability in healthy volunteers is not associated with raised oxidative stress markers
Author(s) -
Wakil A.,
Smith K. A.,
Atkin S. L.,
Kilpatrick E. S.
Publication year - 2012
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2012.01625.x
Subject(s) - interquartile range , urinary system , oxidative stress , medicine , diabetes mellitus , endocrinology , type 2 diabetes
Abstract It is unknown whether glycaemic variability adds to the risk of microvascular complications of diabetes over and above the mean glucose value for a patient. We examined the effect of purposefully induced short‐term glycaemic variability on oxidative stress markers. Eleven healthy subjects underwent three sequential glycaemic states; sustained hyperglycaemia, sustained euglycaemia and variable glycaemia, using glycaemic clamps for 3 h. Twenty‐four hours urinary 8‐isoprostane‐ PGF2α was measured before and after each glycaemic state to assess oxidative stress. The median and interquartile range of the urinary 8‐iso‐ PGF2α in ng/24 h were (1373, 513), (996, 298) and (1227, 472) for the euglycaemic, hyperglycaemic and variable states, respectively. There was no significant difference in urinary isoprostanes between the three different states; mean ranks 20.9, 11.9 and 18.2 for the euglycaemic state, hyperglycaemic state and glycaemic variability state, respectively, p = 0.083. In conclusion, we did not see a significant increase in the urinary isoprostanes when glycaemic variability was induced under controlled conditions in healthy individuals.