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Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes
Author(s) -
Hussey S. E.,
McGee S. L.,
Garnham A.,
McConell G. K.,
Hargreaves M.
Publication year - 2012
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2012.01585.x
Subject(s) - glut4 , skeletal muscle , medicine , endocrinology , type 2 diabetes , activator (genetics) , gene expression , messenger rna , body mass index , diabetes mellitus , receptor , biology , gene , insulin resistance , biochemistry
The aim of the study was to determine the effect of a single bout of exercise on GLUT4 gene expression in muscle of patients with type 2 diabetes (T2D) and control subjects, matched for age and body mass index. Nine patients with T2D and nine control subjects performed 60 min of cycling exercise at ∼55% peak power ( W max ). Skeletal muscle biopsies were obtained at baseline, immediately post and 3‐h post exercise. GLUT4 mRNA expression increased (p < 0.05) to a similar extent immediately post exercise in control (∼60%) and T2D (∼66%) subjects, and remained elevated (p < 0.05) 3‐h post exercise with no differences between groups. Similarly, p‐AMP‐activated protein kinase, p38 mitogen‐activated kinase and proliferator‐activated receptor gamma co‐activator‐alpha mRNA expression were increased (p < 0.05) post exercise, and were not different between the groups. In conclusion, a single bout of exercise increased skeletal muscle GLUT4 mRNA expression in patients with T2D to a similar extent as in control subjects.