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Phosphoprotein enriched in diabetes gene product (Ped/pea‐15) is increased in omental adipose tissue of women with the polycystic ovary syndrome: ex vivo regulation of ped/pea‐15 by glucose, insulin and metformin
Author(s) -
Tan B. K.,
Chen J.,
Adya R.,
Randeva H. S.
Publication year - 2011
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2010.01329.x
Subject(s) - medicine , polycystic ovary , endocrinology , insulin resistance , biology , adipose tissue , insulin , ovary , diabetes mellitus , advanced glycation end product , glycation
Polycystic ovary syndrome (PCOS), the commonest endocrine disorder in women, is characterized by an altered steroid milieu and is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Phosphoprotein enriched in diabetes gene product (Ped/pea‐15) regulates glucose metabolism and is increased in T2DM. Our novel data indicate that Ped/pea‐15 mRNA expression and protein levels are significantly increased in omental adipose tissue (AT) from PCOS women compared to matched controls (p < 0.01); Ped/pea‐15 levels in subcutaneous AT were not significantly different. Furthermore, Ped/pea‐15 mRNA expression and protein levels were higher in omental compared to subcutaneous AT in PCOS subjects (p < 0.01); however, in control subjects, this was not significant. Glucose was predictive of omental AT Ped/pea‐15 mRNA expression (p = 0.045). Importantly, glucose and insulin increased whereas metformin significantly decreased Ped/pea‐15 levels in human omental AT explants. Our findings should serve to promote further research on Ped/pea‐15 biology.