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β‐Cells at the crossroads: choosing between insulin granule production and proliferation
Author(s) -
Liu Yanmei,
Mziaut Hassan,
Ivanova Anna,
Solimena Michele
Publication year - 2009
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2009.01107.x
Subject(s) - insulin , biogenesis , regulator , granule (geology) , hormone , biology , diabetes mellitus , endocrinology , microbiology and biotechnology , medicine , gene , genetics , paleontology
Pancreatic β‐cells are the sole source of insulin, the major hormonal regulator of glycaemia. In physiological and pathological conditions with increased insulin demand, β‐cells adjust their insulin output either through increased insulin secretory granule (ISG) biogenesis and secretion, or hyperplasia. Failure of these compensatory mechanisms eventually results in hyperglycaemia and diabetes mellitus. Both of these major adaptive behaviours are positively regulated by several extrinsic factors, such as glucose, GLP‐1, insulin and growth hormones (GH). Still unclear, however, it is how β‐cells in response to these stimuli opt for one or the other strategy at a given time. Here we review recent advances concerning the factors and pathways that enhance ISG biogenesis and β‐cell replication, and propose the existence of ‘switch factors' that play a key role in regulating the shift between these two adaptive responses.