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Transgenic and other experimental models of pancreas and islet damage
Author(s) -
Herrera P. L.
Publication year - 2009
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2009.01104.x
Subject(s) - pancreas , islet , regeneration (biology) , genetically modified mouse , transgene , biology , computational biology , bioinformatics , microbiology and biotechnology , neuroscience , insulin , genetics , endocrinology , gene
To unravel the cellular and molecular mechanisms involved in β‐cell renewal and expansion throughout life, several different experimental models were devised in the past. A number of experimental approaches and transgenic models have been engineered to trigger specifically pancreatic injury and thus explore regeneration. Globally, three main strategies are followed to induce pancreas damage: surgical, chemical and genetic. Some of the most relevant studies regarding these three approaches are briefly summarized in this short overview. Although significant progress has been achieved in recent years, there is much room for improving our understanding of many fundamental processes regulating β‐cell mass maintenance.